Acetonitrile → 5-[4-(3,5-Dichloro-pyridin-4-ylmethyl)-piperazin-1-yl]-2-furan-2-yl-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-ylamine

HRID 213588Notes

Reaction equation

HRID 213588 reaction equation
[CH3:32][CH2:33][N:34]([CH2:35][CH3:36])[CH2:37][CH3:38].[CH3:39][C:40]#[N:41].[Cl:1][c:2]1[cH:3][n:4][cH:5][c:6]([Cl:10])[c:7]1[CH2:8][Cl:9].[o:11]1[c:12](-[c:16]2[n:17][n:18]3[c:19]([n:20][c:21]([N:25]4[CH2:26][CH2:27][NH:28][CH2:29][CH2:30]4)[n:22][c:23]3[NH2:24])[n:31]2)[cH:13][cH:14][cH:15]1>>[Cl:1][c:2]1[cH:3][n:4][cH:5][c:6]([Cl:10])[c:7]1[CH2:8][N:28]1[CH2:27][CH2:26][N:25]([c:21]2[n:20][c:19]3[n:18]([n:17][c:16](-[c:12]4[o:11][cH:15][cH:14][cH:13]4)[n:31]3)[c:23]([NH2:24])[n:22]2)[CH2:30][CH2:29]1

Participants

5

Reactant 4

HCID 6342AcetonitrileHCID 8471TriethylamineHCID 114490312-Furan-2-yl-5-piperazin-1-yl-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-ylamineHCID 226268533,5-Dichloro-4-(chloromethyl)pyridine

Product 1

HCID 114307365-[4-(3,5-Dichloro-pyridin-4-ylmethyl)-piperazin-1-yl]-2-furan-2-yl-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-ylamine

Sources & evidence

ORD record
ord-f043e531ec974e3ea8713ddfc3de6b3f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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