Hydrochloric Acid → N-(2-(4-fluorophenyl)-2-hydroxy-1-((4-(trifluoromethyl)phenyl)methyl)ethyl)-4-methyl-1-naphthalenecarboxamide

HRID 2136703Notes

Reaction equation

HRID 2136703 reaction equation
[BH4-:36].[CH3:39][OH:40].[Cl:41][Mn:42][Cl:43].[ClH:38].[F:1][c:2]1[cH:3][cH:4][c:5]([C:8]([CH:9]([CH2:10][c:11]2[cH:12][cH:13][c:14]([C:17]([F:18])([F:19])[F:20])[cH:15][cH:16]2)[NH:21][C:22](=[O:23])[c:24]2[cH:25][cH:26][c:27]([CH3:34])[c:28]3[cH:29][cH:30][cH:31][cH:32][c:33]23)=[O:35])[cH:6][cH:7]1.[Na+:37]>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]([CH:9]([CH2:10][c:11]2[cH:12][cH:13][c:14]([C:17]([F:18])([F:19])[F:20])[cH:15][cH:16]2)[NH:21][C:22](=[O:23])[c:24]2[cH:25][cH:26][c:27]([CH3:34])[c:28]3[cH:29][cH:30][cH:31][cH:32][c:33]23)[OH:35])[cH:6][cH:7]1

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 887MethanolHCID 923Sodium ionHCID 24480Manganese (II) chlorideHCID 28123BorohydrideHCID 22261573N-(2-(4-fluorophenyl)-2-oxo-1-((4-(trifluoromethyl)phenyl)methyl)ethyl)-4-methyl-1-naphthalenecarboxamide

Product 1

HCID 22261907N-(2-(4-fluorophenyl)-2-hydroxy-1-((4-(trifluoromethyl)phenyl)methyl)ethyl)-4-methyl-1-naphthalenecarboxamide

Sources & evidence

ORD record
ord-3771e8d0136941c280d03e88d4ace023
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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