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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2136939Generated: October 30, 2026

Tetrahydrofuran → 5-(2,3-Difluorophenyl)-1-(2,2,2-trifluoroethyl)piperidin-2-one

https://huagongshe.com/reaction/2136939

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTetrahydrofuranHCID 8028—
ReactantN-methyl-2-pyrrolidoneHCID 13387—
ReactantLithium ionHCID 28486—
Reactant2,2,2-Trifluoroethyl trifluoromethanesulfonateHCID 80366—
ReactantNpc316347HCID 3280088—
Reactant5-(2,3-Difluorophenyl)piperidin-2-oneHCID 68748426—
Product5-(2,3-Difluorophenyl)-1-(2,2,2-trifluoroethyl)piperidin-2-oneHCID 68747194—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (4/10)
ORD IDord-b861cae23794495fb674f14b5dbac704
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (4/10)