Tetrahydrofuran → 5-(2,3-Difluorophenyl)-1-(2,2,2-trifluoroethyl)piperidin-2-one
Reaction equation
[CH2:39]1[O:40][CH2:41][CH2:42][CH2:43]1.[CH3:16][Si:17]([N-:18][Si:19]([CH3:20])([CH3:21])[CH3:22])([CH3:23])[CH3:24].[CH3:44][N:45]1[CH2:46][CH2:47][CH2:48][C:49]1=[O:50].[F:1][c:2]1[c:3]([CH:9]2[CH2:10][CH2:11][C:12](=[O:15])[NH:13][CH2:14]2)[cH:4][cH:5][cH:6][c:7]1[F:8].[Li+:25].[S:26]([O:27][CH2:34][C:35]([F:36])([F:37])[F:38])([C:28]([F:29])([F:30])[F:31])(=[O:32])=[O:33]>>[F:1][c:2]1[c:3]([CH:9]2[CH2:10][CH2:11][C:12](=[O:15])[N:13]([CH2:34][C:35]([F:36])([F:37])[F:38])[CH2:14]2)[cH:4][cH:5][cH:6][c:7]1[F:8]Participants
7
Sources & evidence
- ORD record
- ord-b861cae23794495fb674f14b5dbac704
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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