Iodoethane → HCID 14442214, compound

HRID 21370Notes

Reaction equation

HRID 21370 reaction equation
[CH3:1][O:2][CH2:3][C:4]1[CH:9]=[CH:8][N:7]=[CH:6][CH:5]=1.[CH2:10](I)[CH3:11]>C(#N)C>[CH2:10]([N:7]1[CH2:8][CH:9]=[C:4]([CH2:3][O:2][CH3:1])[CH2:5][CH2:6]1)[CH3:11]

Participants

4

Reactant 2

HCID 6340IodoethaneHCID 6428374-(Methoxymethyl)pyridine

Product 1

HCID 14442214HCID 14442214, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

6.5 g (0.053 mol) of 4-methoxymethyl pyridine and 9.9 g of ethyl iodide are refluxed in 65 ml of acetonitrile for 1 hour. After the solvent has been distilled off the quaternary salt remaining is taken up in methanol and reduced with sodium borohydride analogously to Example 1 b). 7.8 g (95.2% of theory) of the title compound are obtained (b.p. 85° C./20 mbar).

Workup

  1. distillationAfter the solvent has been distilled off the quaternary salt

Sources & evidence

ORD record
ord-f2833cfb460c421f819e0bbaa4af9e7c
Source dataset
uspto-grants-1995_06
Patent number
US05422353

Reaction notes

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