Lithium ion → 1-[1-Benzyl-3-(3,4-difluorophenyl)piperidin-4-yl]ethanol

HRID 2137506Notes

Reaction equation

HRID 2137506 reaction equation
[Al+3:49].[CH2:1]([N:2]1[CH2:3][CH2:4][CH:5]([CH:6]([OH:7])[CH3:8])[CH:9]([c:10]2[cH:11][cH:12][c:13]([Cl:14])[cH:15][cH:16]2)[CH2:17]1)[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1.[CH2:24]([c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1)[N:31]1[CH2:32][CH:33]([c:40]2[cH:41][c:42]([F:47])[c:43]([F:46])[cH:44][cH:45]2)[CH:34]([C:37]([CH3:38])=[O:39])[CH2:35][CH2:36]1.[H-:48].[H-:51].[H-:52].[H-:53].[Li+:50]>>[CH2:24]([c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1)[N:31]1[CH2:32][CH:33]([c:40]2[cH:41][c:42]([F:47])[c:43]([F:46])[cH:44][cH:45]2)[CH:34]([CH:37]([CH3:38])[OH:39])[CH2:35][CH2:36]1

Participants

6

Reactant 5

HCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 68475389(RS)-1-[(3SR,4SR)-1-Benzyl-3-(4-chloro-phenyl)-piperidin-4-yl]-ethanolHCID 722991511-[1-Benzyl-3-(3,4-difluorophenyl)piperidin-4-yl]ethanone

Product 1

HCID 722991451-[1-Benzyl-3-(3,4-difluorophenyl)piperidin-4-yl]ethanol

Sources & evidence

ORD record
ord-498acafe1abe43ff945104e87306d268
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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