Imidazole → 4-Chloro-2-[[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-phenylpropyl]amino]benzonitrile
Reaction equation
[C:21]([CH3:22])([CH3:23])([CH3:24])[Si:25]([CH3:26])([CH3:27])[Cl:28].[Cl:1][c:2]1[cH:3][c:4]([NH:10][CH:11]([CH2:12][CH2:13][OH:14])[c:15]2[cH:16][cH:17][cH:18][cH:19][cH:20]2)[c:5]([C:6]#[N:7])[cH:8][cH:9]1.[O:34]1[CH2:35][CH2:36][CH2:37][CH2:38]1.[OH2:39].[nH:29]1[cH:30][cH:31][n:32][cH:33]1>>[Cl:1][c:2]1[cH:3][c:4]([NH:10][CH:11]([CH2:12][CH2:13][O:14][Si:25]([C:21]([CH3:22])([CH3:23])[CH3:24])([CH3:26])[CH3:27])[c:15]2[cH:16][cH:17][cH:18][cH:19][cH:20]2)[c:5]([C:6]#[N:7])[cH:8][cH:9]1Participants
6
Sources & evidence
- ORD record
- ord-edff8bd6ec2948b88dd1fd816bf189f9
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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