Dichloromethane → 1-(2-(4-aminopiperidin-1-yl)ethyl)-1,8-naphthyridin-2(1H)-one

HRID 2137953Notes

Reaction equation

HRID 2137953 reaction equation
[Cl:28][CH2:29][Cl:30].[O:1]=[c:2]1[n:3]([CH2:12][CH2:13][N:14]2[CH2:15][CH2:16][CH:17]([NH:20][C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])[CH2:18][CH2:19]2)[c:4]2[n:5][cH:6][cH:7][cH:8][c:9]2[cH:10][cH:11]1.[OH:31][C:32]([C:33]([F:34])([F:35])[F:36])=[O:37]>>[O:1]=[c:2]1[n:3]([CH2:12][CH2:13][N:14]2[CH2:15][CH2:16][CH:17]([NH2:20])[CH2:18][CH2:19]2)[c:4]2[n:5][cH:6][cH:7][cH:8][c:9]2[cH:10][cH:11]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 57815416tert-butyl (1-(2-(2-oxo-1,8-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)carbamate

Product 1

HCID 578152591-(2-(4-aminopiperidin-1-yl)ethyl)-1,8-naphthyridin-2(1H)-one

Sources & evidence

ORD record
ord-26952026f4f54b0c92702ec2400f8e27
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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