Acetic Acid → N2-(6-(4-Chloro-1H-imidazol-1-yl)-5-methoxypyridin-3-yl)-N4-methyl-7-(3,4,5-trifluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine

HRID 2138083Notes

Reaction equation

HRID 2138083 reaction equation
[CH2:41]1[O:42][CH2:43][CH2:44][CH2:45]1.[CH3:37][C:38](=[O:39])[OH:40].[Cl:1][c:2]1[n:3][c:4]([NH:20][CH3:21])[c:5]2[c:6]([n:7]1)[CH:8]([c:11]1[cH:12][c:13]([F:19])[c:14]([F:18])[c:15]([F:17])[cH:16]1)[CH2:9][CH2:10]2.[Cl:22][c:23]1[n:24][cH:25][n:26](-[c:28]2[c:29]([O:35][CH3:36])[cH:30][c:31]([NH2:34])[cH:32][n:33]2)[cH:27]1>>[c:2]1([NH:34][c:31]2[cH:30][c:29]([O:35][CH3:36])[c:28](-[n:26]3[cH:25][n:24][c:23]([Cl:22])[cH:27]3)[n:33][cH:32]2)[n:3][c:4]([NH:20][CH3:21])[c:5]2[c:6]([n:7]1)[CH:8]([c:11]1[cH:12][c:13]([F:19])[c:14]([F:18])[c:15]([F:17])[cH:16]1)[CH2:9][CH2:10]2

Participants

5

Reactant 4

HCID 176Acetic AcidHCID 8028TetrahydrofuranHCID 580754656-(4-chloro-1H-imidazol-1-yl)-5-methoxypyridin-3-amineHCID 580756192-chloro-N-methyl-7-(3,4,5-trifluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine

Product 1

HCID 58075499N2-(6-(4-Chloro-1H-imidazol-1-yl)-5-methoxypyridin-3-yl)-N4-methyl-7-(3,4,5-trifluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine

Sources & evidence

ORD record
ord-35c655c7bf1a4a818ab0350bd560f9c4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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