Dichloromethane → 5-Chloro-1-(2,6-difluorophenyl)-7-(methylthio)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one

HRID 2139041Notes

Reaction equation

HRID 2139041 reaction equation
[C:21](=[O:22])([c:23]1[nH:24][cH:25][cH:26][n:27]1)[c:28]1[nH:29][cH:30][cH:31][n:32]1.[Cl:33][CH2:34][Cl:35].[NH2:1][CH2:2][c:3]1[c:4]([NH:12][c:13]2[c:14]([F:20])[cH:15][cH:16][cH:17][c:18]2[F:19])[n:5][c:6]([S:10][CH3:11])[n:7][c:8]1[Cl:9]>>[NH:1]1[CH2:2][c:3]2[c:4]([n:5][c:6]([S:10][CH3:11])[n:7][c:8]2[Cl:9])[N:12]([c:13]2[c:14]([F:20])[cH:15][cH:16][cH:17][c:18]2[F:19])[C:21]1=[O:22]

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 5250894Bis-(1H-imidazol-2-YL)-methanoneHCID 575305435-(Aminomethyl)-6-chloro-N-(2,6-difluorophenyl)-2-(methylthio)-4-pyrimidinamine

Product 1

HCID 575305005-Chloro-1-(2,6-difluorophenyl)-7-(methylthio)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one

Sources & evidence

ORD record
ord-ae1fc8ff8aca4743964864671a5611ec
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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