Methanol → tert-butyl 5-[2-amino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2,2-diphenylmorpholine-4-carboxylate
Reaction equation
[BH4-:41].[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][C:10]([c:29]2[cH:30][cH:31][cH:32][cH:33][cH:34]2)([c:35]2[cH:36][cH:37][cH:38][cH:39][cH:40]2)[O:11][CH2:12][CH:13]1[CH:14]([CH:15]([CH2:16][c:17]1[cH:18][c:19]([F:24])[cH:20][c:21]([F:23])[cH:22]1)[N+:25]([O-:26])=[O:27])[OH:28].[CH3:44][OH:45].[Na+:42].[Ni:46]([Cl:47])[Cl:48].[OH2:43]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][C:10]([c:29]2[cH:30][cH:31][cH:32][cH:33][cH:34]2)([c:35]2[cH:36][cH:37][cH:38][cH:39][cH:40]2)[O:11][CH2:12][CH:13]1[CH:14]([CH:15]([CH2:16][c:17]1[cH:18][c:19]([F:24])[cH:20][c:21]([F:23])[cH:22]1)[NH2:25])[OH:28]Participants
7
Sources & evidence
- ORD record
- ord-2a1b8805f5f948debe131fb5c14a615a
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
Loading…