Dichloromethane → 5-(6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yloxy)-N-(3-(trifluoromethyl)phenyl)-1H-indole-1-carboxamide

HRID 2139413Notes

Reaction equation

[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][c:10]2[n:11][cH:12][n:13][c:14]([O:17][c:18]3[cH:19][c:20]4[cH:21][cH:22][n:23]([C:27]([NH:28][c:29]5[cH:30][c:31]([C:35]([F:36])([F:37])[F:38])[cH:32][cH:33][cH:34]5)=[O:39])[c:24]4[cH:25][cH:26]3)[c:15]2[CH2:16]1)([CH3:5])([CH3:6])[CH3:7].[Cl:47][CH2:48][Cl:49].[F:40][C:41]([F:42])([F:43])[C:44]([OH:45])=[O:46]>>[NH:8]1[CH2:9][c:10]2[n:11][cH:12][n:13][c:14]([O:17][c:18]3[cH:19][c:20]4[cH:21][cH:22][n:23]([C:27]([NH:28][c:29]5[cH:30][c:31]([C:35]([F:36])([F:37])[F:38])[cH:32][cH:33][cH:34]5)=[O:39])[c:24]4[cH:25][cH:26]3)[c:15]2[CH2:16]1

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 593942384-[1-(3-trifluoromethyl-phenylcarbamoyl)-1H-indol-5-yloxy]-5,7-dihydro pyrrolo[3,4-d]pyrimidine-6-carboxylic acid tert-butyl ester

Product 1

HCID 593944295-(6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yloxy)-N-(3-(trifluoromethyl)phenyl)-1H-indole-1-carboxamide

Sources & evidence

ORD record: ord-83126d9b5d48453f8f57782353c4814d
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (4/10)
DOI: 10.1039/C8SC04228D

Reaction notes

Loading…