2-Methoxypyrimidine-5-boronic acid → 1-(2,5-Dichlorobenzyl)-7-(2-methoxypyrimidin-5-yl)-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine

HRID 2139689Notes

Reaction equation

HRID 2139689 reaction equation
[CH3:21][O:22][c:23]1[n:24][cH:25][c:26]([B:29]([OH:30])[OH:31])[cH:27][n:28]1.[Cl:1][c:2]1[c:3]([CH2:4][N:5]2[c:6]3[c:7]([n:11][cH:12][c:13]([I:15])[cH:14]3)[NH:8][CH2:9][CH2:10]2)[cH:16][c:17]([Cl:20])[cH:18][cH:19]1>>[Cl:1][c:2]1[c:3]([CH2:4][N:5]2[c:6]3[c:7]([n:11][cH:12][c:13](-[c:26]4[cH:25][n:24][c:23]([O:22][CH3:21])[n:28][cH:27]4)[cH:14]3)[NH:8][CH2:9][CH2:10]2)[cH:16][c:17]([Cl:20])[cH:18][cH:19]1

Participants

3

Reactant 2

HCID 27367782-Methoxypyrimidine-5-boronic acidHCID 578860791-(2,5-Dichlorobenzyl)-7-iodo-3,4-dihydro-1H-pyrido[2,3-b]pyrazine

Product 1

HCID 578857971-(2,5-Dichlorobenzyl)-7-(2-methoxypyrimidin-5-yl)-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine

Sources & evidence

ORD record
ord-4d34468793574146800bb825262f18ea
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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