反应详情

A mixture containing 3-(R)-(1-cyano-1,1-diphenylmethyl)piperidine (0.3 g), 2-phenoxyethyl bromide (0.24 g--commercially available), anhydrous potassium carbonate (0.5 g) and acetonitrile (15 ml) was heated under reflux for 5 hours. The mixture was then partitioned between dichloromethane (30 ml) and 10% aqueous potassium carbonate (30 ml), the layers separated, and the aqueous layer extracted with dichloromethane (2×20 ml). The combined dichloromethane extracts were dried (MgSO4) and concentrated in vacuo to give a gum which was purified by column chromatography on silica eluting with dichloromethane containing methanol (0% up to 2%). The product-containing fractions were combined and concentrated in vacuo to give the title compound as a gum, yield 0.254 g.

1. temperatureunder reflux for 5 hours
2. customThe mixture was then partitioned between dichloromethane (30 ml) and 10% aqueous potassium carbonate (30 ml)
3. customthe layers separated
4. extractionthe aqueous layer extracted with dichloromethane (2×20 ml)
5. dry with materialThe combined dichloromethane extracts were dried (MgSO4)
6. concentrationconcentrated in vacuo
7. customto give a gum which
8. customwas purified by column chromatography on silica eluting with dichloromethane
9. additioncontaining methanol (0% up to 2%)
10. concentrationconcentrated in vacuo