Sodium ion → N-(5-bromo-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-2,2-dimethylcyclopropanecarboxamide

HRID 2140096Notes

Reaction equation

HRID 2140096 reaction equation
[Br:31][c:32]1[c:33]([F:42])[c:34]2[c:35]([n:36][cH:37]1)[nH:38][cH:39][c:40]2[NH2:41].[C:43](=[O:44])([O-:45])[O-:46].[CH3:1][C:2]1([CH3:8])[CH:3]([C:5](=[O:6])[OH:7])[CH2:4]1.[CH3:24][CH2:25][N:26]([CH2:27][CH3:28])[CH2:29][CH3:30].[Cl:49][CH2:50][Cl:51].[Na+:47].[Na+:48].[O:9]=[C:10]1[N:11]([P:12]([Cl:13])([N:14]2[CH2:15][CH2:16][O:17][C:18]2=[O:19])=[O:20])[CH2:21][CH2:22][O:23]1>>[CH3:1][C:2]1([CH3:8])[CH:3]([C:5](=[O:6])[NH:41][c:40]2[c:34]3[c:33]([F:42])[c:32]([Br:31])[cH:37][n:36][c:35]3[nH:38][cH:39]2)[CH2:4]1

Participants

8

Reactant 7

HCID 923Sodium ion2×HCID 6344DichloromethaneHCID 8471TriethylamineHCID 19660Carbonate IonHCID 152842Bis(2-oxo-3-oxazolidinyl)phosphinic chlorideHCID 2607082,2-Dimethylcyclopropane-1-carboxylic acidHCID 602052765-bromo-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-amine

Product 1

HCID 60205714N-(5-bromo-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-2,2-dimethylcyclopropanecarboxamide

Sources & evidence

ORD record
ord-aa287b05448745e9bc5452c4e8155e86
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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