3-Bromo-2-fluoro-5-methylpyridine → 8-(2-Fluoro-5-methylpyridin-3-yl)-2-(4-(trifluoromethoxy)phenyl)-2,8-diazaspiro[4.5]decan-1-one
Reaction equation
[Br:23][c:24]1[c:25]([F:31])[n:26][cH:27][c:28]([CH3:30])[cH:29]1.[F:1][C:2]([O:3][c:4]1[cH:5][cH:6][c:7]([N:10]2[C:11](=[O:20])[C:12]3([CH2:13][CH2:14]2)[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]3)[cH:8][cH:9]1)([F:21])[F:22]>>[F:1][C:2]([O:3][c:4]1[cH:5][cH:6][c:7]([N:10]2[C:11](=[O:20])[C:12]3([CH2:13][CH2:14]2)[CH2:15][CH2:16][N:17]([c:24]2[c:25]([F:31])[n:26][cH:27][c:28]([CH3:30])[cH:29]2)[CH2:18][CH2:19]3)[cH:8][cH:9]1)([F:21])[F:22]Participants
3
Sources & evidence
- ORD record
- ord-ef40eeecc4f148cc90aa7f1b78a26276
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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