Hydrochloric Acid → [1-(5-Bromo-2-fluoro-phenyl)-1-difluoromethyl-3-hydroxy-propyl]-carbamic acid tert-butyl ester
Reaction equation
[BH4-:29].[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][C:8]([CH2:9][CH:10]=[CH2:11])([CH:12]([F:13])[F:14])[c:15]1[c:16]([F:22])[cH:17][cH:18][c:19]([Br:21])[cH:20]1)=[O:23].[CH3:35][OH:36].[Cl:32][CH2:33][Cl:34].[ClH:31].[Na+:28].[Na+:30].[O-:24][C:25]([OH:26])=[O:27].[O:37]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][C:8]([CH2:9][CH2:10][OH:24])([CH:12]([F:13])[F:14])[c:15]1[c:16]([F:22])[cH:17][cH:18][c:19]([Br:21])[cH:20]1)=[O:23]Participants
9
Reactant 8
Product 1
Sources & evidence
- ORD record
- ord-1f01eff34f194219a76813cb200b3d48
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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