反应详情

Thionyl chloride (0.5 ml) was added, dropwise, to a! stirred solution of 4-hydroxy-3-methoxyphenethyl alcohol (0.83 g--commercially available) in dichloromethane (50 ml). When the addition was complete, the mixture was heated under reflux for 3 hours. On cooling to room temperature, the mixture was concentrated in vacuo to give a gum which was purified by column chromatography on silica eluting with dichloromethane containing methanol (0% up to 2%). The product-containing fractions were combined and concentrated in vacuo to give the title compound as an oil, yield 0.36 g.

1. additionWhen the addition
2. temperaturethe mixture was heated
3. temperatureunder reflux for 3 hours
4. concentrationthe mixture was concentrated in vacuo
5. customto give a gum which
6. customwas purified by column chromatography on silica eluting with dichloromethane
7. additioncontaining methanol (0% up to 2%)
8. concentrationconcentrated in vacuo