Hydrochloric Acid → HCID 136186418, compound

HRID 21407Notes

Reaction equation

HRID 21407 reaction equation
C(=[N:4][N:5]=[C:6]1[NH:10][C:9](=[O:11])[CH2:8][N:7]1[CH2:12][C:13]([O:15]C)=O)(C)C.[OH-].[Na+].Cl>CO>[N:7]12[CH2:8][C:9](=[O:11])[NH:10][C:6]1=[N:5][NH:4][C:13](=[O:15])[CH2:12]2

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 136128236HCID 136128236, compound

Product 1

HCID 136186418HCID 136186418, compoundYield 48.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 226 mg of 2-isopropylidenehydrazono-1-methoxycarbonylmethylimidazolidin-4-one were added 10 ml of methanol and 1 ml of a 2N sodium hydroxide solution, and the mixture was stirred for 16 hours at room temperature. The reaction mixture obtained was neutralized with the addition of 1N hydrochloric acid, concentrated under reduced pressure, and the residue formed was recrystallized from methanol to obtain 75 mg of 1,4,5,7-tetraazabicyclo[4,3,0]nonan-5-ene-3,8-dione.

Workup

  1. customThe reaction mixture obtained
  2. concentrationconcentrated under reduced pressure
  3. customthe residue formed
  4. customwas recrystallized from methanol

Sources & evidence

ORD record
ord-0d3420bc319f42e5a163210c44784772
Source dataset
uspto-grants-1995_06
Patent number
US05422360

Reaction notes

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