Dichloromethane → 3-(3-Chloro-5-fluorophenyl)pyrrolidin-3-ol

HRID 2140819Notes

Reaction equation

HRID 2140819 reaction equation
[Cl:1][c:2]1[cH:3][c:4]([C:9]2([OH:21])[CH2:10][N:11]([C:14]([O:15][C:16]([CH3:17])([CH3:18])[CH3:19])=[O:20])[CH2:12][CH2:13]2)[cH:5][c:6]([F:8])[cH:7]1.[Cl:29][CH2:30][Cl:31].[OH:22][C:23]([C:24]([F:25])([F:26])[F:27])=[O:28]>>[Cl:1][c:2]1[cH:3][c:4]([C:9]2([OH:21])[CH2:10][NH:11][CH2:12][CH2:13]2)[cH:5][c:6]([F:8])[cH:7]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 67402932Tert-butyl 3-(3-chloro-5-fluorophenyl)-3-hydroxypyrrolidine-1-carboxylate

Product 1

HCID 685156533-(3-Chloro-5-fluorophenyl)pyrrolidin-3-ol

Sources & evidence

ORD record
ord-a10e10dbdc6845979044f9ed00e01fb2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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