反应详情

To 230 mg of 2-benzylidenehydrazono-3-ethoxycarbonylmethyl-1-methoxycarbonylmethylimidazolidin-4-one obtained in step (1) of Example 7 was added 10 ml of 0.5N hydrochloric acid, the mixture was subjected to a steam distillation for 40 minutes. The reaction mixture obtained was concentrated under reduced pressure, and the residue formed was charged on silica gel column chromatography and eluted with a mixture of chloroform and ethyl acetate at 1:2 by volume to obtain 60 mg of 7-ethoxycarbonylmethyl-1,4,5,7-tetraazabicyclo[4,3,0]-nonan-5-ene-3,8-dione.

1. distillationthe mixture was subjected to a steam distillation for 40 minutes
2. customThe reaction mixture obtained
3. concentrationwas concentrated under reduced pressure
4. customthe residue formed
5. additionwas charged on silica gel column chromatography
6. washeluted with a mixture of chloroform and ethyl acetate at 1:2 by volume