Tetrahydrofuran → 3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-5-[(2-hydroxy-acetylamino)-methyl]-N-(2-hydroxy-ethoxy)-benzamide
Reaction equation
[C:19]([Si:20]([CH3:21])([CH3:22])[O:24][CH2:25][CH2:26][O:27][NH:28][C:29]([c:30]1[c:31]([NH:44][c:45]2[c:46]([F:52])[cH:47][c:48]([I:51])[cH:49][cH:50]2)[c:32]([F:43])[c:33]([F:42])[c:34]([CH2:36][NH:37][C:38]([CH2:39][OH:40])=[O:41])[cH:35]1)=[O:53])([CH3:23])([CH3:54])[CH3:55].[CH2:2]([N+:3]([CH2:4][CH2:5][CH2:6][CH3:7])([CH2:8][CH2:9][CH2:10][CH3:11])[CH2:12][CH2:13][CH2:14][CH3:15])[CH2:16][CH2:17][CH3:18].[F-:1].[O:56]1[CH2:57][CH2:58][CH2:59][CH2:60]1>>[OH:24][CH2:25][CH2:26][O:27][NH:28][C:29]([c:30]1[c:31]([NH:44][c:45]2[c:46]([F:52])[cH:47][c:48]([I:51])[cH:49][cH:50]2)[c:32]([F:43])[c:33]([F:42])[c:34]([CH2:36][NH:37][C:38]([CH2:39][OH:40])=[O:41])[cH:35]1)=[O:53]Participants
5
Sources & evidence
- ORD record
- ord-1e8d89409387445e80c6e7d10dadbf8b
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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