Methanol → 3-[5-chloro-1-(5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)spiro[2H-indole-3,4'-piperidine]-1'-yl]propan-1-amine

HRID 2141315Notes

Reaction equation

HRID 2141315 reaction equation
[CH3:40][NH2:41].[CH3:42][OH:43].[Cl:1][c:2]1[cH:3][c:4]2[c:8]([cH:9][cH:10]1)[N:7]([c:11]1[c:12]3[c:13]([n:14][cH:15][n:16]1)[CH2:17][CH2:18][CH:19]3[CH3:20])[CH2:6][C:5]21[CH2:21][CH2:22][N:23]([CH2:26][CH2:27][CH2:28][N:29]2[C:30](=[O:31])[c:32]3[c:33]([cH:34][cH:35][cH:36][cH:37]3)[C:38]2=[O:39])[CH2:24][CH2:25]1>>[Cl:1][c:2]1[cH:3][c:4]2[c:8]([cH:9][cH:10]1)[N:7]([c:11]1[c:12]3[c:13]([n:14][cH:15][n:16]1)[CH2:17][CH2:18][CH:19]3[CH3:20])[CH2:6][C:5]21[CH2:21][CH2:22][N:23]([CH2:26][CH2:27][CH2:28][NH2:29])[CH2:24][CH2:25]1

Participants

4

Reactant 3

HCID 887MethanolHCID 6329MethylamineHCID 687645742-[3-[5-chloro-1-(5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)spiro[2H-indole-3,4'-piperidine]-1'-yl]propyl]isoindole-1,3-dione

Product 1

HCID 687635773-[5-chloro-1-(5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)spiro[2H-indole-3,4'-piperidine]-1'-yl]propan-1-amine

Sources & evidence

ORD record
ord-43194aa655e34fd3bb0bf9208229eda6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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