1,2-Dimethoxyethane → 6-[2-(4-Cyano-phenyl)-2H-pyrazol-3-yl]-5-methyl-3-oxo-4-(3-trifluoromethyl-phenyl)-3,4-dihydro-pyrazine-2-carboxylic acid methylamide

HRID 2141514Notes

Reaction equation

HRID 2141514 reaction equation
[Br:1][c:2]1[c:3]([CH3:23])[n:4](-[c:13]2[cH:14][c:15]([C:19]([F:20])([F:21])[F:22])[cH:16][cH:17][cH:18]2)[c:5](=[O:12])[c:6]([C:8](=[O:9])[NH:10][CH3:11])[n:7]1.[C:24](#[N:25])[c:26]1[cH:27][cH:28][c:29](-[n:32]2[n:33][cH:34][cH:35][c:36]2[B:37]([OH:38])[OH:39])[cH:30][cH:31]1.[C:40](=[O:41])([O-:42])[O-:43].[CH3:46][O:47][CH2:48][CH2:49][O:50][CH3:51].[Cs+:44].[Cs+:45]>>[c:2]1(-[c:36]2[n:32](-[c:29]3[cH:28][cH:27][c:26]([C:24]#[N:25])[cH:31][cH:30]3)[n:33][cH:34][cH:35]2)[c:3]([CH3:23])[n:4](-[c:13]2[cH:14][c:15]([C:19]([F:20])([F:21])[F:22])[cH:16][cH:17][cH:18]2)[c:5](=[O:12])[c:6]([C:8](=[O:9])[NH:10][CH3:11])[n:7]1

Participants

6

Reactant 5

HCID 80711,2-DimethoxyethaneHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 667386596-Bromo-N,5-dimethyl-3-oxo-4-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxamideHCID 66738661[1-(4-cyanophenyl)-1H-pyrazol-5-yl]boronic acid

Product 1

HCID 248901406-[2-(4-Cyano-phenyl)-2H-pyrazol-3-yl]-5-methyl-3-oxo-4-(3-trifluoromethyl-phenyl)-3,4-dihydro-pyrazine-2-carboxylic acid methylamide

Sources & evidence

ORD record
ord-1b7269da41064175bd2889e552b70382
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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