Dichloromethane → Trifluoroacetic acid

HRID 2141907Notes

Reaction equation

HRID 2141907 reaction equation
[CH2:35]([Cl:36])[Cl:37].[F:1][C:2]([C:3](=[O:4])[OH:5])([F:6])[F:7].[cH:8]1[n:9][cH:10][cH:11][c:12]2[cH:13][c:14]([N:18]3[CH2:19][CH2:20][C:21]4([CH2:22][CH2:23][N:24]([C:26]([O:27][C:28]([CH3:29])([CH3:30])[CH3:31])=[O:32])[CH2:25]4)[CH2:33][CH2:34]3)[cH:15][cH:16][c:17]12>>[F:1][C:2]([C:3](=[O:4])[OH:5])([F:6])[F:7].[cH:8]1[n:9][cH:10][cH:11][c:12]2[cH:13][c:14]([N:18]3[CH2:19][CH2:20][C:21]4([CH2:22][CH2:23][NH:24][CH2:25]4)[CH2:33][CH2:34]3)[cH:15][cH:16][c:17]12

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 66700964tert-Butyl 8-(isoquinolin-6-yl)-2,8-diazaspiro[4.5]decane-2-carboxylate

Product 2

HCID 6422Trifluoroacetic acidHCID 595057388-Isoquinolin-6-yl-2,8-diazaspiro[4.5]decane

Sources & evidence

ORD record
ord-9d7f21e6f31b4c75b80dd9f720aff183
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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