Dichloromethane → N-(2-{3-[4-(4-chloro-phenyl)-piperazin-1-yl]-phenyl}-3,3-dimethyl-1,2,3,4-tetrahydroquinoline-6-carbonyl)-methanesulfonamide

HRID 2142455Notes

Reaction equation

HRID 2142455 reaction equation
[CH3:35][S:36](=[O:37])(=[O:38])[NH2:39].[CH3:40][N:41]([CH3:42])[c:43]1[cH:44][cH:45][n:46][cH:47][cH:48]1.[Cl:1][c:2]1[cH:3][cH:4][c:5]([N:8]2[CH2:9][CH2:10][N:11]([c:14]3[cH:15][c:16]([CH:20]4[NH:21][c:22]5[cH:23][cH:24][c:25]([C:32](=[O:33])[OH:34])[cH:26][c:27]5[CH2:28][C:29]4([CH3:30])[CH3:31])[cH:17][cH:18][cH:19]3)[CH2:12][CH2:13]2)[cH:6][cH:7]1.[Cl:49][CH2:50][Cl:51]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([N:8]2[CH2:9][CH2:10][N:11]([c:14]3[cH:15][c:16]([CH:20]4[NH:21][c:22]5[cH:23][cH:24][c:25]([C:32](=[O:33])[NH:39][S:36]([CH3:35])(=[O:37])=[O:38])[cH:26][c:27]5[CH2:28][C:29]4([CH3:30])[CH3:31])[cH:17][cH:18][cH:19]3)[CH2:12][CH2:13]2)[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 142844-(Dimethylamino)pyridineHCID 72879MethanesulfonamideHCID 584762472-{3-[4-(4-Chloro-phenyl)-piperazin-1-yl]-phenyl}-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carboxylic acid

Product 1

HCID 53491975N-(2-{3-[4-(4-chloro-phenyl)-piperazin-1-yl]-phenyl}-3,3-dimethyl-1,2,3,4-tetrahydroquinoline-6-carbonyl)-methanesulfonamide

Sources & evidence

ORD record
ord-d82f80c801e043cca2d9142a2f89384f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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