Tetrahydrofuran → 4-chloro-N-(1-(2-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-oxoethyl)-1H-1,2,4-triazol-3-yl)cyclopenta-1,3-dienecarboxamide

HRID 2142894Notes

Reaction equation

HRID 2142894 reaction equation
[CH2:32]1[O:33][CH2:34][CH2:35][CH2:36]1.[CH3:19][N:20]1[CH2:21][CH2:22][CH:23]([N:26]2[CH2:27][CH2:28][NH:29][CH2:30][CH2:31]2)[CH2:24][CH2:25]1.[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:7](=[O:8])[NH:9][c:10]2[n:11][n:12]([CH2:15][C:16](=[O:17])[OH:18])[cH:13][n:14]2)[s:6]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:7](=[O:8])[NH:9][c:10]2[n:11][n:12]([CH2:15][C:16](=[O:18])[N:29]3[CH2:28][CH2:27][N:26]([CH:23]4[CH2:22][CH2:21][N:20]([CH3:19])[CH2:25][CH2:24]4)[CH2:31][CH2:30]3)[cH:13][n:14]2)[s:6]1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 5663241-(1-Methyl-4-piperidinyl)piperazineHCID 59698827{3-[(5-Chloro-thiophene-2-carbonyl)-amino]-[1,2,4]triazol-1-yl}-acetic acid

Product 1

HCID 426431754-chloro-N-(1-(2-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-oxoethyl)-1H-1,2,4-triazol-3-yl)cyclopenta-1,3-dienecarboxamide

Sources & evidence

ORD record
ord-8798a6b3f7194cabb915559e9de11b12
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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