p-Toluenesulfonic acid → 4-[4-Fluoro-2-(tetrahydro-pyran-4-yloxy)-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methylester

HRID 2142978Notes

Reaction equation

HRID 2142978 reaction equation
[CH2:42]1[O:43][CH2:44][CH2:45][O:46][CH2:47]1.[Cl:16][c:17]1[c:18]2[c:19]([n:20][cH:21][n:22]1)[s:23][c:24]([C:27](=[O:28])[O:29][CH3:30])[c:25]2[CH3:26].[F:1][c:2]1[cH:3][c:4]([O:9][CH:10]2[CH2:11][CH2:12][O:13][CH2:14][CH2:15]2)[c:5]([NH2:6])[cH:7][cH:8]1.[c:31]1([CH3:32])[cH:33][cH:34][c:35]([S:36]([OH:37])(=[O:38])=[O:39])[cH:40][cH:41]1>>[F:1][c:2]1[cH:3][c:4]([O:9][CH:10]2[CH2:11][CH2:12][O:13][CH2:14][CH2:15]2)[c:5]([NH:6][c:17]2[c:18]3[c:19]([n:20][cH:21][n:22]2)[s:23][c:24]([C:27](=[O:28])[O:29][CH3:30])[c:25]3[CH3:26])[cH:7][cH:8]1

Participants

5

Reactant 4

HCID 6101p-Toluenesulfonic acidHCID 312751,4-DioxaneHCID 2759834Methyl 4-chloro-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylateHCID 584130794-Fluoro-2-(oxan-4-yloxy)aniline

Product 1

HCID 461820444-[4-Fluoro-2-(tetrahydro-pyran-4-yloxy)-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methylester

Sources & evidence

ORD record
ord-fde36b671c044d368b42928f3c2b25cf
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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