反应详情

温度

75 °C

A solution of N-(3-hydroxy-4-methoxybenzenesulphonyl)- 1,2-dihydroindole (0.2 g) and 3-phenoxypropylbromide (0.15 g) in N,N-dimethylformamide (20 ml) was treated with cesium carbonate (0.3 g) and heated at 75° C. overnight. The solvent was removed in vacuo and the residue partitioned between dichloromethane (30 ml) and water (15 ml). The organic phase was washed with brine (15 ml) then dried over magnesium sulphate and concentrated in vacuo. The residue was purified using column chromatography eluting with dichloromethane to yield the title compound as a white solid (0.25 g).

1. customThe solvent was removed in vacuo
2. customthe residue partitioned between dichloromethane (30 ml) and water (15 ml)
3. washThe organic phase was washed with brine (15 ml)
4. dry with materialthen dried over magnesium sulphate
5. concentrationconcentrated in vacuo
6. customThe residue was purified
7. washeluting with dichloromethane