Dichloromethane → 6-Chloro-4-(piperazin-1-yl)quinoline

HRID 2143358Notes

Reaction equation

HRID 2143358 reaction equation
[C:13]([O:14][C:15](=[O:16])[N:20]1[CH2:21][CH2:22][NH:23][CH2:24][CH2:25]1)([CH3:17])([CH3:18])[CH3:19].[Cl:1][c:2]1[cH:3][cH:4][n:5][c:6]2[cH:7][cH:8][c:9]([Cl:12])[cH:10][c:11]12.[Cl:33][CH2:34][Cl:35].[OH:26][C:27]([C:28]([F:29])([F:30])[F:31])=[O:32]>>[c:2]1([N:20]2[CH2:21][CH2:22][NH:23][CH2:24][CH2:25]2)[cH:3][cH:4][n:5][c:6]2[cH:7][cH:8][c:9]([Cl:12])[cH:10][c:11]12

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 143452tert-Butyl piperazine-1-carboxylateHCID 9360754,6-Dichloroquinoline

Product 1

HCID 114706516-Chloro-4-(piperazin-1-yl)quinoline

Sources & evidence

ORD record
ord-c8bfa37bbf3f4fed98d19d388b3f3531
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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