Hydrochloric Acid → [1-(3-Bromo-phenyl)-2,2-difluoro-1-hydroxymethyl-ethyl]-carbamic acid tert-butyl ester
Reaction equation
[BH4-:27].[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][C:8]([CH:9]=[CH2:10])([CH:11]([F:12])[F:13])[c:14]1[cH:15][c:16]([Br:20])[cH:17][cH:18][cH:19]1)=[O:21].[CH3:33][OH:34].[Cl:30][CH2:31][Cl:32].[ClH:29].[Na+:26].[Na+:28].[O-:22][C:23]([OH:24])=[O:25]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][C:8]([CH2:9][OH:22])([CH:11]([F:12])[F:13])[c:14]1[cH:15][c:16]([Br:20])[cH:17][cH:18][cH:19]1)=[O:21]Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-592ad42cf1fc44ed89ed01c124aed680
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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