Dichloromethane → 2-(4-(Bromomethyl)-2-nitrophenyl)-5-(1-phenylcyclopropyl)-thiazolo[5,4-b]pyridine

HRID 2143504Notes

Reaction equation

[C:49]([Br:50])([Br:51])([Br:52])[Br:53].[Cl:54][CH2:55][Cl:56].[N+:1](=[O:2])([O-:3])[c:4]1[cH:5][c:6]([CH2:28][OH:29])[cH:7][cH:8][c:9]1-[c:10]1[s:11][c:12]2[n:13][c:14]([C:19]3([c:22]4[cH:23][cH:24][cH:25][cH:26][cH:27]4)[CH2:20][CH2:21]3)[cH:15][cH:16][c:17]2[n:18]1.[c:30]1([P:31]([c:32]2[cH:33][cH:34][cH:35][cH:36][cH:37]2)[c:38]2[cH:39][cH:40][cH:41][cH:42][cH:43]2)[cH:44][cH:45][cH:46][cH:47][cH:48]1>>[N+:1](=[O:2])([O-:3])[c:4]1[cH:5][c:6]([CH2:28][Br:50])[cH:7][cH:8][c:9]1-[c:10]1[s:11][c:12]2[n:13][c:14]([C:19]3([c:22]4[cH:23][cH:24][cH:25][cH:26][cH:27]4)[CH2:20][CH2:21]3)[cH:15][cH:16][c:17]2[n:18]1

Participants

Reactant 4

HCID 6344Dichloromethane

HCID 11205Carbon tetrabromide

HCID 11776Triphenylphosphine

HCID 67111784(3-Nitro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine-2-yl)phenyl)methanol

Product 1

HCID 671118432-(4-(Bromomethyl)-2-nitrophenyl)-5-(1-phenylcyclopropyl)-thiazolo[5,4-b]pyridine

Sources & evidence

ORD record: ord-4ac80ceb0f584f0f8528a08a93845b64
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (4/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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