Potassium Cation → 6-(4-(Azetidin-3-yloxy)benzyl)-2-oxa-6-azaspiro[3.3]heptane

HRID 2144065Notes

Reaction equation

HRID 2144065 reaction equation
[CH2:1]1[O:2][CH2:3][C:4]12[CH2:5][N:6]([CH2:8][c:9]1[cH:10][cH:11][c:12]([O:13][CH:14]3[CH2:15][N:16]([C:18]([O:19][C:20]([CH3:21])([CH3:22])[CH3:23])=[O:24])[CH2:17]3)[cH:25][cH:26]1)[CH2:7]2.[Cl:40][CH2:41][Cl:42].[F:27][C:28]([F:29])([F:30])[C:31]([OH:32])=[O:33].[K+:34].[K+:35].[O-:36][C:37]([O-:38])=[O:39]>>[CH2:1]1[O:2][CH2:3][C:4]12[CH2:5][N:6]([CH2:8][c:9]1[cH:10][cH:11][c:12]([O:13][CH:14]3[CH2:15][NH:16][CH2:17]3)[cH:25][cH:26]1)[CH2:7]2

Participants

6

Reactant 5

HCID 813Potassium Cation2×HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 19660Carbonate IonHCID 59563505tert-Butyl 3-(4-(2-oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenoxy)azetidine-1-carboxylate

Product 1

HCID 595635036-(4-(Azetidin-3-yloxy)benzyl)-2-oxa-6-azaspiro[3.3]heptane

Sources & evidence

ORD record
ord-0716ca89d9b7491494143e9fb2bacc2a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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