Sodium ion → tert-Butyl 9,10-dichloro-6-[2-(4-fluorophenoxy)ethyl]-1,4,5,6-tetrahydroazepino[4,5-b]indole-3(2H)-carboxylate

HRID 214424Notes

Reaction equation

HRID 214424 reaction equation
[Cl:3][c:4]1[c:5]([Cl:25])[c:6]2[c:7]3[c:8]([nH:9][c:10]2[cH:11][cH:12]1)[CH2:13][CH2:14][N:15]([C:18](=[O:19])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])[CH2:16][CH2:17]3.[F:26][c:27]1[cH:28][cH:29][c:30]([O:31][CH2:32][CH2:33][Br:34])[cH:35][cH:36]1.[H-:1].[Na+:2].[O:37]=[CH:38][N:39]([CH3:40])[CH3:41]>>[Cl:3][c:4]1[c:5]([Cl:25])[c:6]2[c:7]3[c:8]([n:9]([CH2:33][CH2:32][O:31][c:30]4[cH:29][cH:28][c:27]([F:26])[cH:36][cH:35]4)[c:10]2[cH:11][cH:12]1)[CH2:13][CH2:14][N:15]([C:18](=[O:19])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])[CH2:16][CH2:17]3

Participants

6

Reactant 5

HCID 923Sodium ionHCID 6228DimethylformamideHCID 166653HydrideHCID 20641711-(2-Bromoethoxy)-4-fluorobenzeneHCID 22396855tert-butyl 9,10-dichloro-1,4,5,6-tetrahydroazepino[4,5-b]indole-3(2H)-carboxylate

Product 1

HCID 22396705tert-Butyl 9,10-dichloro-6-[2-(4-fluorophenoxy)ethyl]-1,4,5,6-tetrahydroazepino[4,5-b]indole-3(2H)-carboxylate

Sources & evidence

ORD record
ord-8b3e86f5f52c49d586c842393a30c0ef
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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