Dichloromethane → N-(4-chlorophenyl)piperidin-4-amine

HRID 2144373Notes

Reaction equation

HRID 2144373 reaction equation
[CH2:22]([Cl:23])[Cl:24].[Cl:1][c:2]1[cH:3][cH:4][c:5]([NH:8][CH:9]2[CH2:10][CH2:11][N:12]([C:15]([O:16][C:17]([CH3:18])([CH3:19])[CH3:20])=[O:21])[CH2:13][CH2:14]2)[cH:6][cH:7]1.[OH:25][C:26]([C:27]([F:28])([F:29])[F:30])=[O:31]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([NH:8][CH:9]2[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]2)[cH:6][cH:7]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 1491503Tert-butyl 4-(4-chlorophenylamino)piperidine-1-carboxylate

Product 1

HCID 7183033N-(4-chlorophenyl)piperidin-4-amine

Sources & evidence

ORD record
ord-36f5bec5dd5a402ea3bc579253c67501
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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