Ethylene Glycol → tert-Butyl 4-[4-(2-hydroxyethoxy)-1,2,5-thiadiazol-3-yl]-1-piperazinecarboxylate

HRID 2144770Notes

Reaction equation

HRID 2144770 reaction equation
[CH3:30][CH2:31][O:32][C:33]([CH3:34])=[O:35].[Cl:1][c:2]1[c:3]([N:7]2[CH2:8][CH2:9][N:10]([C:13](=[O:14])[O:15][C:16]([CH3:17])([CH3:18])[CH3:19])[CH2:11][CH2:12]2)[n:4][s:5][n:6]1.[OH:20][CH2:21][CH2:22][OH:23].[cH:24]1[cH:25][cH:26][n:27][cH:28][cH:29]1>>[c:2]1([O:23][CH2:22][CH2:21][OH:20])[c:3]([N:7]2[CH2:8][CH2:9][N:10]([C:13](=[O:14])[O:15][C:16]([CH3:17])([CH3:18])[CH3:19])[CH2:11][CH2:12]2)[n:4][s:5][n:6]1

Participants

5

Reactant 4

HCID 174Ethylene GlycolHCID 1049PyridineHCID 8857Ethyl AcetateHCID 15524001Tert-butyl 4-(4-chloro-1,2,5-thiadiazol-3-yl)piperazine-1-carboxylate

Product 1

HCID 22036393tert-Butyl 4-[4-(2-hydroxyethoxy)-1,2,5-thiadiazol-3-yl]-1-piperazinecarboxylate

Sources & evidence

ORD record
ord-b961cf75f5274ae499e84682a4e38d52
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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