Sodium ion → 3-fluoro-4-[(3-chloro-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]aniline

HRID 2144911Notes

Reaction equation

HRID 2144911 reaction equation
[Cl:3][c:4]1[cH:5][nH:6][c:7]2[n:8][cH:9][cH:10][c:11]([O:13][c:14]3[c:15]([F:27])[cH:16][c:17]([NH:20][C:21](=[O:22])[C:23]([F:24])([F:25])[F:26])[cH:18][cH:19]3)[c:12]12.[Na+:2].[O:28]1[CH2:29][CH2:30][CH2:31][CH2:32]1.[OH-:1]>>[Cl:3][c:4]1[cH:5][nH:6][c:7]2[n:8][cH:9][cH:10][c:11]([O:13][c:14]3[c:15]([F:27])[cH:16][c:17]([NH2:20])[cH:18][cH:19]3)[c:12]12

Participants

5

Reactant 4

HCID 923Sodium ionHCID 961HydroxideHCID 8028TetrahydrofuranHCID 59741002N-{4-[(3-Chloro-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]-3-fluorophenyl}-2,2,2-trifluoroacetamide

Product 1

HCID 597410163-fluoro-4-[(3-chloro-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]aniline

Sources & evidence

ORD record
ord-0c15c41d564b41c7ab006bde54b21c0b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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