Acetic Acid → Tert-butyl 4-[5-(2-hydroxyphenyl)-2-methylphenyl]piperazine-1-carboxylate

HRID 2144990Notes

Reaction equation

HRID 2144990 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[cH:15][c:16](-[c:21]3[c:22]([O:27][CH2:28][c:29]4[cH:30][cH:31][cH:32][cH:33][cH:34]4)[cH:23][cH:24][cH:25][cH:26]3)[cH:17][cH:18][c:19]2[CH3:20])[CH2:12][CH2:13]1.[CH3:35][C:36](=[O:37])[OH:38].[CH3:39][OH:40].[CH3:41][CH2:42][O:43][C:44](=[O:45])[CH3:46]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[cH:15][c:16](-[c:21]3[c:22]([OH:27])[cH:23][cH:24][cH:25][cH:26]3)[cH:17][cH:18][c:19]2[CH3:20])[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 176Acetic AcidHCID 887MethanolHCID 8857Ethyl AcetateHCID 69243526Tert-butyl 4-[2-methyl-5-(2-phenylmethoxyphenyl)phenyl]piperazine-1-carboxylate

Product 1

HCID 69243961Tert-butyl 4-[5-(2-hydroxyphenyl)-2-methylphenyl]piperazine-1-carboxylate

Sources & evidence

ORD record
ord-c14d1fbd3b3e4696806c0a23ea3fd9a4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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