HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-Fluoro-4-(methylsulfonyl)benzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-Fluoro-4-(methylsulphonyl)benzoic acid | HCID 28355932 | — |
| Product | 2-Fluoro-4-(methylsulfonyl)benzoyl chloride | HCID 18977942 | — |
Reaction Steps
A mixture of 2-fluoro-4-methylsulphonylbenzoic acid (6.0 g) and thionyl chloride were stirred and heated at reflux for 2 hours. The mixture was cooled and evaporated to dryness. Toluene was added and the solvent re-evaporated to give 2-fluoro-4-methylsulphonylbenzoyl chloride (6.5 g) as a brown solid which was not further purified.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05424276 |
| Source dataset | uspto-grants-1995_06 |
| ORD ID | ord-43cc33749cf145b5b22e0b2966828f0f |
| Source note | uspto-grants-1995_06 |