Dichloromethane → 3-{4-[2-(4-chloro-phenyl)-7-oxo-7H-thieno[2,3-c]pyridin-6-yl]-phenylcarbamoyl}-pyrrolidine-1-carboxylic acid tert-butyl ester

HRID 2145265Notes

Reaction equation

HRID 2145265 reaction equation
[Br:16][c:17]1[cH:18][cH:19][c:20](-[n:23]2[c:24](=[O:39])[c:25]3[c:26]([cH:27][cH:28]2)[cH:29][c:30](-[c:32]2[cH:33][cH:34][c:35]([Cl:38])[cH:36][cH:37]2)[s:31]3)[cH:21][cH:22]1.[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([C:13]([NH2:14])=[O:15])[CH2:11][CH2:12]1.[C:40](=[O:41])([O-:42])[O-:43].[CH2:46]1[O:47][CH2:48][CH2:49][O:50][CH2:51]1.[Cl:52][CH2:53][Cl:54].[Cs+:44].[Cs+:45].[Cu:55][I:56]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([C:13]([NH:14][c:17]2[cH:18][cH:19][c:20](-[n:23]3[c:24](=[O:39])[c:25]4[c:26]([cH:27][cH:28]3)[cH:29][c:30](-[c:32]3[cH:33][cH:34][c:35]([Cl:38])[cH:36][cH:37]3)[s:31]4)[cH:21][cH:22]2)=[O:15])[CH2:11][CH2:12]1

Participants

8

Reactant 7

HCID 6344DichloromethaneHCID 19660Carbonate IonHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 312751,4-DioxaneHCID 104967Cesium cation2×HCID 4571096Tert-butyl 3-carbamoylpyrrolidine-1-carboxylateHCID 689531476-(4-Bromo-phenyl)-2-(4-chloro-phenyl)-6H-thieno[2,3-c]pyridin-7-one

Product 1

HCID 689499533-{4-[2-(4-chloro-phenyl)-7-oxo-7H-thieno[2,3-c]pyridin-6-yl]-phenylcarbamoyl}-pyrrolidine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-1be2523340ce4da9818e23773c51e719
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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