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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2145326Generated: November 3, 2026

Tetrahydrofuran → 4-{4-[4-(4-Hydroxy-tetrahydro-thiopyran-4-yl)-3-methyl-phenoxymethyl]-phenyl}-piperidine-1-carboxylic acid tert-butyl ester

https://huagongshe.com/reaction/2145326

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTetrahydrofuranHCID 8028—
ReactantTetrahydrothiopyran-4-oneHCID 66173—
Reactant4-[4-(4-Bromo-3-methyl-phenoxymethyl)-phenyl]-piperidine-1-carboxylic acid tert-butyl esterHCID 68812278—
ReactantButyllithiumHCID 178418339—
Product4-{4-[4-(4-Hydroxy-tetrahydro-thiopyran-4-yl)-3-methyl-phenoxymethyl]-phenyl}-piperidine-1-carboxylic acid tert-butyl esterHCID 68816254—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (4/10)
ORD IDord-89ff7a6326da4ff49b19603efcd28b95
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (4/10)