Tetrahydrofuran → 4-{4-[4-(4-Hydroxy-tetrahydro-thiopyran-4-yl)-3-methyl-phenoxymethyl]-phenyl}-piperidine-1-carboxylic acid tert-butyl ester

HRID 2145326Notes

Reaction equation

HRID 2145326 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([c:14]2[cH:15][cH:16][c:17]([CH2:20][O:21][c:22]3[cH:23][c:24]([CH3:29])[c:25]([Br:28])[cH:26][cH:27]3)[cH:18][cH:19]2)[CH2:12][CH2:13]1.[CH2:42]1[O:43][CH2:44][CH2:45][CH2:46]1.[CH3:30][CH2:31][CH2:32][CH2:33][Li:34].[S:35]1[CH2:36][CH2:37][C:38](=[O:41])[CH2:39][CH2:40]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([c:14]2[cH:15][cH:16][c:17]([CH2:20][O:21][c:22]3[cH:23][c:24]([CH3:29])[c:25]([C:38]4([OH:41])[CH2:37][CH2:36][S:35][CH2:40][CH2:39]4)[cH:26][cH:27]3)[cH:18][cH:19]2)[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 66173Tetrahydrothiopyran-4-oneHCID 688122784-[4-(4-Bromo-3-methyl-phenoxymethyl)-phenyl]-piperidine-1-carboxylic acid tert-butyl esterHCID 178418339Butyllithium

Product 1

HCID 688162544-{4-[4-(4-Hydroxy-tetrahydro-thiopyran-4-yl)-3-methyl-phenoxymethyl]-phenyl}-piperidine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-89ff7a6326da4ff49b19603efcd28b95
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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