Dichloromethane → 1-Cbz-4-(3-aminophenoxy)-piperidine

HRID 2145481Notes

Reaction equation

HRID 2145481 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][C:9](=[O:10])[N:11]1[CH2:12][CH2:13][CH:14]([O:17][c:18]2[cH:19][c:20]([NH:24][C:25]([O:26][C:27]([CH3:28])([CH3:29])[CH3:30])=[O:31])[cH:21][cH:22][cH:23]2)[CH2:15][CH2:16]1.[Cl:39][CH2:40][Cl:41].[OH:32][C:33]([C:34]([F:35])([F:36])[F:37])=[O:38]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][C:9](=[O:10])[N:11]1[CH2:12][CH2:13][CH:14]([O:17][c:18]2[cH:19][c:20]([NH2:24])[cH:21][cH:22][cH:23]2)[CH2:15][CH2:16]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 68454608N-Boc-3-[(1-Cbz-4-piperidyl)oxy]aniline

Product 1

HCID 684534411-Cbz-4-(3-aminophenoxy)-piperidine

Sources & evidence

ORD record
ord-07494e25c6ec4a6dbcf775ef4839ab9e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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