Magnesium Cation → Biphenyl-2-carboxylic acid [4-(5H,11H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10-carbonyl)-3-chloro-phenyl]-amide

HRID 2145646Notes

Reaction equation

HRID 2145646 reaction equation
[CH2:56]([Cl:57])[Cl:58].[CH:15]([N:16]([CH2:17][CH3:18])[CH:19]([CH3:20])[CH3:21])([CH3:22])[CH3:23].[Mg+2:54].[Mg+2:55].[Si:49]([O-:50])([O-:51])([O-:52])[O-:53].[c:24]1(-[c:43]2[cH:44][cH:45][cH:46][cH:47][cH:48]2)[c:25]([C:30](=[O:31])[NH:32][c:33]2[cH:34][c:35]([Cl:42])[c:36]([C:37](=[O:38])[Cl:39])[cH:40][cH:41]2)[cH:26][cH:27][cH:28][cH:29]1.[cH:1]1[cH:2][cH:3][n:4]2[c:5]1[CH2:6][NH:7][c:8]1[c:9]([cH:11][cH:12][cH:13][cH:14]1)[CH2:10]2>>[cH:1]1[cH:2][cH:3][n:4]2[c:5]1[CH2:6][N:7]([C:37]([c:36]1[c:35]([Cl:42])[cH:34][c:33]([NH:32][C:30]([c:25]3[c:24](-[c:43]4[cH:44][cH:45][cH:46][cH:47][cH:48]4)[cH:29][cH:28][cH:27][cH:26]3)=[O:31])[cH:41][cH:40]1)=[O:38])[c:8]1[c:9]([cH:11][cH:12][cH:13][cH:14]1)[CH2:10]2

Participants

7

Reactant 6

HCID 888Magnesium Cation2×HCID 6344DichloromethaneHCID 81531DiisopropylethylamineHCID 104812SilicateHCID 1554704810,11-Dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepineHCID 220996004-[([1,1'-Biphenyl]-2-carbonyl)amino]-2-chlorobenzoyl chloride

Product 1

HCID 10459252Biphenyl-2-carboxylic acid [4-(5H,11H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10-carbonyl)-3-chloro-phenyl]-amide

Sources & evidence

ORD record
ord-04cca24ee56c4580a9d27eb1c20d4911
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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