Dichloromethane → Tert-butyl 2-[[2-(6-bromo-3-pyridinyl)-1-cyanoethyl]carbamoyl]piperidine-1-carboxylate

HRID 2145959Notes

Reaction equation

HRID 2145959 reaction equation
[CH3:1][CH2:2][N:3]([CH2:4][CH3:5])[CH2:6][CH3:7].[Cl:45][CH2:46][Cl:47].[Cl:8][S:9]([NH:10][C:11](=[O:12])[O:13][CH3:14])(=[O:15])=[O:16].[NH2:17][C:18]([CH:19]([CH2:20][c:21]1[cH:22][n:23][c:24]([Br:27])[cH:25][cH:26]1)[NH:28][C:29](=[O:30])[CH:31]1[N:32]([C:37](=[O:38])[O:39][C:40]([CH3:41])([CH3:42])[CH3:43])[CH2:33][CH2:34][CH2:35][CH2:36]1)=[O:44]>>[N:17]#[C:18][CH:19]([CH2:20][c:21]1[cH:22][n:23][c:24]([Br:27])[cH:25][cH:26]1)[NH:28][C:29](=[O:30])[CH:31]1[N:32]([C:37](=[O:38])[O:39][C:40]([CH3:41])([CH3:42])[CH3:43])[CH2:33][CH2:34][CH2:35][CH2:36]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 10702364Methyl chlorosulfonylcarbamateHCID 76700711Tert-butyl 2-[[1-amino-3-(6-bromo-3-pyridinyl)-1-oxopropan-2-yl]carbamoyl]piperidine-1-carboxylate

Product 1

HCID 76700725Tert-butyl 2-[[2-(6-bromo-3-pyridinyl)-1-cyanoethyl]carbamoyl]piperidine-1-carboxylate

Sources & evidence

ORD record
ord-1f3d97936e984b8382a15ac5ddcb15bc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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