Benzaldehyde → 3-[(1-Benzyl-piperidin-4-yl)-(4-methyl-cyclohexanecarbonyl)-amino]-5-phenyl-thiophene-2-carboxylic acid methyl ester

HRID 2147117Notes

Reaction equation

HRID 2147117 reaction equation
[C:40]([O:41][BH-:42]([O:43][C:44](=[O:45])[CH3:46])[O:47][C:48](=[O:49])[CH3:50])(=[O:51])[CH3:52].[CH3:1][O:2][C:3](=[O:4])[c:5]1[s:6][c:7](-[c:26]2[cH:27][cH:28][cH:29][cH:30][cH:31]2)[cH:8][c:9]1[N:10]([CH:11]1[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]1)[C:17](=[O:18])[CH:19]1[CH2:20][CH2:21][CH:22]([CH3:25])[CH2:23][CH2:24]1.[CH:32](=[O:33])[c:34]1[cH:35][cH:36][cH:37][cH:38][cH:39]1.[Cl:54][CH:55]([Cl:56])[CH3:57].[Na+:53]>>[CH3:1][O:2][C:3](=[O:4])[c:5]1[s:6][c:7](-[c:26]2[cH:27][cH:28][cH:29][cH:30][cH:31]2)[cH:8][c:9]1[N:10]([CH:11]1[CH2:12][CH2:13][N:14]([CH2:32][c:34]2[cH:35][cH:36][cH:37][cH:38][cH:39]2)[CH2:15][CH2:16]1)[C:17](=[O:18])[CH:19]1[CH2:20][CH2:21][CH:22]([CH3:25])[CH2:23][CH2:24]1

Participants

6

Reactant 5

HCID 240BenzaldehydeHCID 923Sodium ionHCID 63651,1-DichloroethaneHCID 2724942TriacetoxyborohydrideHCID 59752320HCID 59752320, compound

Product 1

HCID 597523513-[(1-Benzyl-piperidin-4-yl)-(4-methyl-cyclohexanecarbonyl)-amino]-5-phenyl-thiophene-2-carboxylic acid methyl ester

Sources & evidence

ORD record
ord-668e18f332bb4068ae293d8f9415a36d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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