Dichloromethane → 4,4-Dimethyl-7-{2-[(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-amino]-benzoylamino}-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester
Reaction equation
[B-:41]([F:42])([F:43])([F:44])[F:45].[C:21]([CH3:22])([CH3:23])([CH3:24])[O:25][C:26](=[O:27])[N:28]1[CH2:29][c:30]2[cH:31][c:32]([NH2:40])[cH:33][cH:34][c:35]2[C:36]([CH3:38])([CH3:39])[CH2:37]1.[CH:63]([N:64]([CH2:65][CH3:66])[CH:67]([CH3:68])[CH3:69])([CH3:70])[CH3:71].[Cl:72][CH2:73][Cl:74].[n:46]1([O:47][C:48]([N:49]([CH3:50])[CH3:51])=[N+:52]([CH3:53])[CH3:54])[c:55]2[cH:56][cH:57][cH:58][cH:59][c:60]2[n:61][n:62]1.[nH:1]1[cH:2][c:3]([CH2:10][NH:11][c:12]2[c:13]([C:14](=[O:15])[OH:16])[cH:17][cH:18][cH:19][cH:20]2)[c:4]2[c:5]1[n:6][cH:7][cH:8][cH:9]2>>[nH:1]1[cH:2][c:3]([CH2:10][NH:11][c:12]2[c:13]([C:14](=[O:16])[NH:40][c:32]3[cH:31][c:30]4[c:35]([cH:34][cH:33]3)[C:36]([CH3:38])([CH3:39])[CH2:37][N:28]([C:26]([O:25][C:21]([CH3:22])([CH3:23])[CH3:24])=[O:27])[CH2:29]4)[cH:17][cH:18][cH:19][cH:20]2)[c:4]2[c:5]1[n:6][cH:7][cH:8][cH:9]2Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-4c1f61c168ec4d62ac6e78fbf2ed95cf
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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