Dichloromethane → 6-Methoxy-7-(3-methylsulphonylpropoxy)-3-((pivaloyloxy)methyl)-3,4-dihydroquinazolin-4-one

HRID 2147440Notes

Reaction equation

HRID 2147440 reaction equation
[CH2:50]([Cl:51])[Cl:52].[CH3:42][S:43](=[O:44])(=[O:45])[CH2:46][CH2:47][CH2:48][OH:49].[OH:20][c:21]1[c:22]([O:40][CH3:41])[cH:23][c:24]2[c:25](=[O:39])[n:26]([CH2:31][O:32][C:33]([C:34]([CH3:35])([CH3:36])[CH3:37])=[O:38])[cH:27][n:28][c:29]2[cH:30]1.[c:1]1([P:2]([c:3]2[cH:4][cH:5][cH:6][cH:7][cH:8]2)[c:9]2[cH:10][cH:11][cH:12][cH:13][cH:14]2)[cH:15][cH:16][cH:17][cH:18][cH:19]1>>[O:20]([c:21]1[c:22]([O:40][CH3:41])[cH:23][c:24]2[c:25](=[O:39])[n:26]([CH2:31][O:32][C:33]([C:34]([CH3:35])([CH3:36])[CH3:37])=[O:38])[cH:27][n:28][c:29]2[cH:30]1)[CH2:48][CH2:47][CH2:46][S:43]([CH3:42])(=[O:44])=[O:45]

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 11776TriphenylphosphineHCID 2004243-(Methylsulfonyl)-1-propanolHCID 10804576(7-Hydroxy-6-methoxy-4-oxoquinazolin-3(4H)-yl)methyl pivalate

Product 1

HCID 220305896-Methoxy-7-(3-methylsulphonylpropoxy)-3-((pivaloyloxy)methyl)-3,4-dihydroquinazolin-4-one

Sources & evidence

ORD record
ord-479279c5875b4b7e8d57bf2d06be053c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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