Hydrochloric Acid → isopropyl 2-(3-(4-(1H-indazol-5-ylamino)quinazolin-2-yl)phenoxy)acetate

HRID 2148738Notes

Reaction equation

HRID 2148738 reaction equation
[CH2:43]1[O:44][CH2:45][CH2:46][O:47][CH2:48]1.[CH:1]([CH3:2])([CH3:3])[O:4][C:5]([CH2:6][O:7][c:8]1[cH:9][c:10](-[c:14]2[n:15][c:16]3[cH:17][cH:18][cH:19][cH:20][c:21]3[c:22]([NH:24][c:25]3[cH:26][c:27]4[cH:28][n:29][n:30]([C:34]([O:35][C:36]([CH3:37])([CH3:38])[CH3:39])=[O:40])[c:31]4[cH:32][cH:33]3)[n:23]2)[cH:11][cH:12][cH:13]1)=[O:41].[ClH:42]>>[CH:1]([CH3:2])([CH3:3])[O:4][C:5]([CH2:6][O:7][c:8]1[cH:9][c:10](-[c:14]2[n:15][c:16]3[cH:17][cH:18][cH:19][cH:20][c:21]3[c:22]([NH:24][c:25]3[cH:26][c:27]4[cH:28][n:29][nH:30][c:31]4[cH:32][cH:33]3)[n:23]2)[cH:11][cH:12][cH:13]1)=[O:41]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 59361962tert-butyl 5-(2-(3-(2-isopropoxy-2-oxoethoxy)phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

Product 1

HCID 59361953isopropyl 2-(3-(4-(1H-indazol-5-ylamino)quinazolin-2-yl)phenoxy)acetate

Sources & evidence

ORD record
ord-ec44dc081eb74bfd9836c3df3196a9cf
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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