Dichloromethane → 2-Chloro-8-(2,2-dimethylpiperazin-1-ylmethyl)-9-methyl-6-morpholin-4-yl-9H-purine

HRID 2149046Notes

Reaction equation

HRID 2149046 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][C:10]([CH3:32])([CH3:33])[N:11]([CH2:14][c:15]2[n:16]([CH3:31])[c:17]3[n:18][c:19]([Cl:30])[n:20][c:21]([N:24]4[CH2:25][CH2:26][O:27][CH2:28][CH2:29]4)[c:22]3[n:23]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:41][CH2:42][Cl:43].[F:34][C:35]([F:36])([F:37])[C:38]([OH:39])=[O:40]>>[NH:8]1[CH2:9][C:10]([CH3:32])([CH3:33])[N:11]([CH2:14][c:15]2[n:16]([CH3:31])[c:17]3[n:18][c:19]([Cl:30])[n:20][c:21]([N:24]4[CH2:25][CH2:26][O:27][CH2:28][CH2:29]4)[c:22]3[n:23]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 596057974-(2-Chloro-9-methyl-6-morpholin-4-yl-9H-purin-8-ylmethyl)-3,3-dimethyl-piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 596054502-Chloro-8-(2,2-dimethylpiperazin-1-ylmethyl)-9-methyl-6-morpholin-4-yl-9H-purine

Sources & evidence

ORD record
ord-57417684d1c8411cbaca7db140a396b6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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